Crosslinking of human fibrin: Evidence for intermolecular crosslinking involving α-chains

Covalent crosslinking of von Willebrand factor to fibrin.

Factor XIIIa crosslinks a limited number of substrates via epsilon(gamma-glutamyl)-lysyl bond formation. It crosslinks fibrin to itself, alpha 2-plasmin inhibitor and fibronectin to fibrin, and fibronectin to collagen. Results presented here show that plasma von Willebrand factor (vWF) is a substrate for factor XIIIa and can be crosslinked to fibrin during gel formation. vWF-fibrin crosslinking...

Crosslinking strategies facilitate tunable structural properties of fibrin microthreads.

A significant challenge in the design of biomimetic scaffolds is combining morphologic, mechanical, and biochemical cues into a single construct to promote tissue regeneration. In this study, we analyzed the effects of different crosslinking conditions on fibrin biopolymer microthreads to create morphologic scaffolds with tunable mechanical properties that are designed for directional cell guid...

Crosslinking for recurrent keratoconus.

Collagen Crosslinking for Keratoconus

In this issue of JOVR, Derakhshan and co-authors 1 describe the results of crosslinking for patients with early keratoconus. Collagen crosslinking is a recently described technique of corneal tissue strengthening using riboflavin as a photosensitizer and ultraviolet A (UVA) radiation to promote the formation of intra-and interfibrillar covalent bonds by photosensitized oxidation. 2 To date, it ...

Crosslinking of XLPE

he undergrounding of energy transmission cables is widely recognized as a good means to provide reliable supplies of power at a low total cost [1], [2]. As utilities increasingly acknowledge this and install many more high voltage (HV) and extra high voltage (EHV) cables, they will face a major challenge: namely, sourcing the increased amount of high quality power cable with the cable manufactu...